| 000 | 07186cam a22005294i 4500 | ||
|---|---|---|---|
| 001 | 1263610 | ||
| 003 | EG-GaU | ||
| 005 | 20211103101425.0 | ||
| 008 | 041119s2005 ii a b 101 0 eng | ||
| 010 | _a 2004062719 | ||
| 020 | _a9780841238992 (alk. paper) | ||
| 020 | _a0841238995 (alk. paper) | ||
| 020 | _a0195686985 (alk. paper) | ||
| 020 | _a978195686985 (alk. paper) | ||
| 035 | _a(OCoLC)57069166 | ||
| 040 |
_aDLC _cDLC _dOCLCQ _dUKM _dBAKER _dC#P _dEG-GaU _beng _erda |
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| 041 | 0 | _aeng | |
| 082 | 0 | 4 |
_223 _a615.2 _bM.E.D. |
| 245 | 0 | 0 |
_aMedicinal inorganic chemistry / _cEditor Jonathan L. Sessler, Susan R. Doctrow, Thomas J. McMurry, Stephen J. Lippard. |
| 264 | 1 |
_aNew Delhi : _bAmerican Chemical Society : _bDistributed by CBS publishers & Distributors, _cc2005. |
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| 300 |
_aix, 453 pages, [8] pages of plates : _billustrations (some color) ; _c24 cm |
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| 336 |
_atext _btxt _2rdacontent |
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| 337 |
_aunmediated _bn _2rdamedia |
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| 338 |
_avolume _bnc _2rdacarrier |
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| 490 | 1 |
_aACS symposium series ; _v903 |
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| 500 | _a"Sponsored by the ACS Divisions of Inorganic Chemistry, Inc. and Medicinal Chemistry." | ||
| 504 | _aIncludes bibliographical references and indexes. | ||
| 505 |
_t1. Metal Ion Chemistry for Sustaining Life / _rStephen J. Lippard -- _t2. Medicinal Inorganic Chemistry: Promises and Challenges / _rJohn W. Kozarich -- _t3. Metals in Medicine: Biomedical Significance and Inorganic Chemistry / _rPeter C. Preusch -- _t4. Discovery and Development of Third-Generation Platinum Antitumor Agents with Oral Activity / _rChristen M. Giandomenico and Ernest Wong -- _t5. Brain Iron as an Endrogenous Contrast Agent in High Field MRI / _rJohn F. Schenck -- _t6. Platinum Anticancer Drugs: From Laboratory to Clinic / _rNicholas Farrell -- _t7. Mechanistic Studies of Pt and Ru Compounds with Antitumor Properties / _r Jan Reedik -- _t8. Mechanistic Studies of Motexafin Gadolinium (Xcyrin): A Redox Active Agent That Reacts with Electron-Rich Biological Substrates / _rDarren J. Magda, Nikolay Gerasimchuk, Zhong Wang, Jonathan L. Sessler, and Richard A. Miller -- _t9. Bile Acids at Work: Development of a New Intravascular MRI Contrast Agent / _rPier Lucio Anelli, Marino Brocchetta, Vito Lorusso, Giuseppe Manfredi, Alberto Morisetti, Pierfrancesco Morosini, Marcella Murru, Daniela Palano, and Massimo Visigalli -- _t10. Water Exchange is the Key Parameter in the Design of Next-Generation MRI Agents / _rA. Dean Sherry, Shanrong Zhang, and Mark Woods -- _t11. Targeted Molecular Imaging with MRI / _rPeter Caravan -- _t12. Synthesis and Development of Gadomer: A Dendritic MRI Contrast Agent / _rJohannes Platzek and Heribert Schmitt-Willich -- _t13. Amyloid Precursor Protein and Ferritin Translation: Implications for Metals and Alzheimer's Disease Therapeutics / _rJack T. Rogers -- _t14. Anticopper Therapy with Tetrathiomolybdate for Wilson's Disease, Cancer, and Diseases of Inflammation and Fibrosis / _rGeorge J. Brewer -- _t15. Heme Detoxification in Malaria: A Target Rich Environment / _rClare Kenny Carney, Lisa Pasierb, and David Wright -- _t16. Heme as a Trigger and Target of the Antimalarial Peroxide Artemisinin / _rAnne Robert, Francoise Benoit-Vical, and Bernard Meunier -- _t17. Administration of Mn Polyyrin and Mn Texaphyrin at Symptom Onset Extends Survival of ALS Mice / _rJohn P. Crow - _t18. Salen Manganese Complexes: Multifunctional Catalytic Antioxidants Protective in Models for Neurodegenerative Diseases of Aging / _rSusan R. Doctorow, Michael Baudry, Karl Huffman, Bernard Malfroy, and Simon Melov -- _t19. Metal Deficient Copper-Zinc Superixide Dismutase and Familial Amyotrophic Lateral Sclerosis: Pathogenic SOD1 Oligomerization through Non-Native Protein-Protein Interactions / _rP. John Hart and Joan Selverstone Valentine -- _t20. Impact of the Lipophilicity of Desferrithiocin Anaglogues on Iron Clearance / _r Raymond J. Bergeron, Jan Wiegand, James S. McManis, William R. Weimar, Jeong-Hyun Park, Eileen Eiler-McManis, Jennifer Bergeron, and Gary M. Brittenham -- _t21. In Vivo Coordination Chemistry and Biocalization of Bis(ligand)oxovanadium(IV) Complexes for Diabetes Treatment / _rKatherine H. Thompson, Barry D. Liboiron, Graeme R. Hanson, and Chris Orvig -- _t22. Targeting Melanoma via Metal-Based Stress / _rPatrick J. Farmer, Daniel Brayton, Christina Moore, Donny Williams, Babbak Shahandeh, Dazhi Cen, and Frank Meyskens, Jr. -- _t23. Medicinal Applications of Metal Complexes of N-Heterocyclic Carbenes / _r Wiley J. Youngs, Claire A. Tesslier, Jared C. Garrison, Carol A. Quezada, Abdulkareem Melaiye, Semih Durmus, Matthew J. Panzer, and Aysegul Kascatan-Nebioglu. |
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| 520 | _a"This book, a compilation by experts in the field, is designed to provide an introduction to the area of medicinal inorganic chemistry and to summarize current, state-of-the-art developments in the field. Medicinal inorganic chemistry represents a key thrust area in medicine and biological inorganic chemistry. It is one of great current excitement and achievement. The field of metals in medicine represents an approximate $3 billion dollar a year industry, with successes in the area of Tc- and Gd-based imaging agents and Pt-based cancer therapeutics being major contributors to this bottom line. It has become increasingly apparent, however, that metal-based pharmaceuticals can play a prominent role in areas outside of imaging and oncology, including in those associated with the diagnosis and treatment of metabolism- and genetic disorders, cardiovascular disease, gene therapy, inflammation, reperfusion injury, stroke, diabetes, ALS, malaria, and neurological disease to name but a few. A objective of this book, therefore, is to highlight these opportunities for future advances and to foster further interactions between those working in the metal-based drug development, including imaging agents, and those engaged in the more classic pharmaceutical industries."--Publisher description. | ||
| 650 | 1 | 2 |
_aInorganic Chemicals _xpharmacology _0https://id.nlm.nih.gov/mesh/D007287Q000494 _91424 |
| 650 | 1 | 2 |
_aOrganometallic Compounds _xpharmacology _0https://id.nlm.nih.gov/mesh/D009942Q000494 _91425 |
| 650 | 2 | 2 |
_aInorganic Chemicals _xtherapeutic use _0https://id.nlm.nih.gov/mesh/D007287Q000627 _91426 |
| 650 | 2 | 2 |
_aMinerals _xpharmacology _0https://id.nlm.nih.gov/mesh/D008903Q000494 _91427 |
| 650 | 2 | 2 |
_aOrganometallic Compounds _xtherapeutic use _0https://id.nlm.nih.gov/mesh/D009942Q000627 _91428 |
| 655 | 2 |
_aCongress _0https://id.nlm.nih.gov/mesh/D016423 _91429 |
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| 700 | 1 |
_aSessler, Jonathan L., _eeditor. _91430 |
|
| 700 | 1 |
_aDoctrow, Susan R., _eeditor. _91431 |
|
| 700 | 1 |
_aMcMurry, Thomas J., _eeditor. _91432 |
|
| 700 | 1 |
_aLippard, Stephen J., _eeditor. _91433 |
|
| 710 | 2 |
_aAmerican Chemical Society. _bDivision of Inorganic Chemistry. _91434 |
|
| 710 | 2 |
_aAmerican Chemical Society. _bDivision of Medicinal Chemistry. _91435 |
|
| 830 | 0 |
_aACS symposium series ; _v903. _91436 |
|
| 856 | 4 | 1 |
_uhttps://library.gu.edu.eg/cgi-bin/koha/opac-retrieve-file.pl?id=cf0e265b9673df79ecb8001585e2e391 _zGet the E-Book |
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