"Sponsored by the ACS Divisions of Inorganic Chemistry, Inc. and Medicinal Chemistry."

Includes bibliographical references and indexes.

1. Metal Ion Chemistry for Sustaining Life / Stephen J. Lippard -- 2. Medicinal Inorganic Chemistry: Promises and Challenges / John W. Kozarich -- 3. Metals in Medicine: Biomedical Significance and Inorganic Chemistry / Peter C. Preusch -- 4. Discovery and Development of Third-Generation Platinum Antitumor Agents with Oral Activity / Christen M. Giandomenico and Ernest Wong -- 5. Brain Iron as an Endrogenous Contrast Agent in High Field MRI / John F. Schenck -- 6. Platinum Anticancer Drugs: From Laboratory to Clinic / Nicholas Farrell -- 7. Mechanistic Studies of Pt and Ru Compounds with Antitumor Properties / Jan Reedik -- 8. Mechanistic Studies of Motexafin Gadolinium (Xcyrin): A Redox Active Agent That Reacts with Electron-Rich Biological Substrates / Darren J. Magda, Nikolay Gerasimchuk, Zhong Wang, Jonathan L. Sessler, and Richard A. Miller -- 9. Bile Acids at Work: Development of a New Intravascular MRI Contrast Agent / Pier Lucio Anelli, Marino Brocchetta, Vito Lorusso, Giuseppe Manfredi, Alberto Morisetti, Pierfrancesco Morosini, Marcella Murru, Daniela Palano, and Massimo Visigalli -- 10. Water Exchange is the Key Parameter in the Design of Next-Generation MRI Agents / A. Dean Sherry, Shanrong Zhang, and Mark Woods -- 11. Targeted Molecular Imaging with MRI / Peter Caravan -- 12. Synthesis and Development of Gadomer: A Dendritic MRI Contrast Agent / Johannes Platzek and Heribert Schmitt-Willich -- 13. Amyloid Precursor Protein and Ferritin Translation: Implications for Metals and Alzheimer's Disease Therapeutics / Jack T. Rogers -- 14. Anticopper Therapy with Tetrathiomolybdate for Wilson's Disease, Cancer, and Diseases of Inflammation and Fibrosis / George J. Brewer -- 15. Heme Detoxification in Malaria: A Target Rich Environment / Clare Kenny Carney, Lisa Pasierb, and David Wright -- 16. Heme as a Trigger and Target of the Antimalarial Peroxide Artemisinin / Anne Robert, Francoise Benoit-Vical, and Bernard Meunier -- 17. Administration of Mn Polyyrin and Mn Texaphyrin at Symptom Onset Extends Survival of ALS Mice / John P. Crow - 18. Salen Manganese Complexes: Multifunctional Catalytic Antioxidants Protective in Models for Neurodegenerative Diseases of Aging / Susan R. Doctorow, Michael Baudry, Karl Huffman, Bernard Malfroy, and Simon Melov -- 19. Metal Deficient Copper-Zinc Superixide Dismutase and Familial Amyotrophic Lateral Sclerosis: Pathogenic SOD1 Oligomerization through Non-Native Protein-Protein Interactions / P. John Hart and Joan Selverstone Valentine -- 20. Impact of the Lipophilicity of Desferrithiocin Anaglogues on Iron Clearance / Raymond J. Bergeron, Jan Wiegand, James S. McManis, William R. Weimar, Jeong-Hyun Park, Eileen Eiler-McManis, Jennifer Bergeron, and Gary M. Brittenham -- 21. In Vivo Coordination Chemistry and Biocalization of Bis(ligand)oxovanadium(IV) Complexes for Diabetes Treatment / Katherine H. Thompson, Barry D. Liboiron, Graeme R. Hanson, and Chris Orvig -- 22. Targeting Melanoma via Metal-Based Stress / Patrick J. Farmer, Daniel Brayton, Christina Moore, Donny Williams, Babbak Shahandeh, Dazhi Cen, and Frank Meyskens, Jr. -- 23. Medicinal Applications of Metal Complexes of N-Heterocyclic Carbenes / Wiley J. Youngs, Claire A. Tesslier, Jared C. Garrison, Carol A. Quezada, Abdulkareem Melaiye, Semih Durmus, Matthew J. Panzer, and Aysegul Kascatan-Nebioglu.

"This book, a compilation by experts in the field, is designed to provide an introduction to the area of medicinal inorganic chemistry and to summarize current, state-of-the-art developments in the field. Medicinal inorganic chemistry represents a key thrust area in medicine and biological inorganic chemistry. It is one of great current excitement and achievement. The field of metals in medicine represents an approximate $3 billion dollar a year industry, with successes in the area of Tc- and Gd-based imaging agents and Pt-based cancer therapeutics being major contributors to this bottom line. It has become increasingly apparent, however, that metal-based pharmaceuticals can play a prominent role in areas outside of imaging and oncology, including in those associated with the diagnosis and treatment of metabolism- and genetic disorders, cardiovascular disease, gene therapy, inflammation, reperfusion injury, stroke, diabetes, ALS, malaria, and neurological disease to name but a few. A objective of this book, therefore, is to highlight these opportunities for future advances and to foster further interactions between those working in the metal-based drug development, including imaging agents, and those engaged in the more classic pharmaceutical industries."--Publisher description.