MARC details
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| fixed length control field |
06214nam a22003137i 4500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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20250903153534.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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250817s2023 flua|||ff|||| 00| 0 eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
9781032398877 |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
EG-GaU |
| Transcribing agency |
EG-GaU |
| Modifying agency |
EG-GaU |
| Description conventions |
rda |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
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| Edition number |
23 |
| Classification number |
615.7 |
| Item number |
W.R.Q |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
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| Personal name |
Wu, Rongling |
| Relator term |
AUTHOR |
| 9 (RLIN) |
63036 |
| 245 10 - TITLE STATEMENT |
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| Title |
Quantitative methods for precision medicine : |
| Remainder of title |
pharmacogenomics in action / |
| Statement of responsibility, etc. |
Rongling Wu |
| 250 ## - EDITION STATEMENT |
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| Edition statement |
First edition. |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
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| Place of production, publication, distribution, manufacture |
Boca Raton : |
| Name of producer, publisher, distributor, manufacturer |
C&H/CRC Press, |
| Date of production, publication, distribution, manufacture, or copyright notice |
2023. |
| 300 ## - PHYSICAL DESCRIPTION |
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| Extent |
xv, 289 pages : |
| Other physical details |
Illustrations (black and white); |
| Dimensions |
24 cm |
| 336 ## - CONTENT TYPE |
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| Source |
rdacontent |
| Content type term |
text |
| Content type code |
txt |
| 337 ## - MEDIA TYPE |
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| Source |
rdamedia |
| Media type term |
unmediated |
| Media type code |
n |
| 338 ## - CARRIER TYPE |
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| Source |
rdacarrier |
| Carrier type term |
volume |
| Carrier type code |
nc |
| 490 ## - SERIES STATEMENT |
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| Series statement |
Chapman & Hall/CRC biostatistics series |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
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| Bibliography, etc. note |
Includes bibliographical references and index.<br/> |
| 505 ## - FORMATTED CONTENTS NOTE |
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| Formatted contents note |
1. Methodological Foundation of Precision Medicine. 1.1. Interpersonal variability in drug response. 1.2. Mechanistic modelling of drug response. 1.3 Statistical models for mapping drug response. 1.4 Network mapping of drug response. 1.5 Conclusions and Outlook. Part I: Pharmacokinetic–Pharmacodynamic Pharmacogenetics. 2. Pharmacogenetic Dissection by Functional Mapping. 2.1. Introduction. 2.2. Quantitative Genetics. 2.3. A General Framework for Functional Mapping. 2.4 Pharmacogenetic Application of Functional Mapping. 2.5. High-dimensional Functional Mapping. 2.6. Concluding Remarks. 3. A Multiscale Model of Pharmacokinetic-Pharmacodynamic Mapping. 3.3. Heterochronopharmacodynamic Mapping. 3.4. Mapping Multifaceted Drug Reactions. 3.5. Concluding Remarks. 4. Pharmacogenetic Mapping of Missing Longitudinal Data. 4.1 Introduction. 4.2. Strategies for Modeling Non-Ignorable Dropout Data. 4.3. Haplotyping Drug Response Using the Pattern-Mixture Model. 4.4. Haplotyping Drug Response Using the Selection Model. 4.5. Concluding Remarks. 5. Systems Mapping of Drug Response. 5.1. Introduction. 5.2. ODE Modeling of PK/PD Machineries. 5.3. Systems Mapping: Model and Algorithm. 5.4. Stochastic Systems Mapping. 5.5. Concluding Remarks. Part II. Network Pharmacogenetics. 6. Network Mapping of Drug Response. 6.1. Introduction. 6.2. Functional Graph Theory. 6.3. Functional Pharmacogenetic Interaction Networks: An Example. 6.4. Fine-Grained Dissection of Pharmacogenetic Networks. 6.5. Modularity Theory and Dunbar’s law. 6.6. Concluding Remarks. 7. Learning Individualized Pharmacogenetic Networks. 7.1. Introduction. 7.2. A Framework for Network Inference. 7.3. Coalescing Individualized Networks into Stratification-Specific Networks. 7.4. Computer Simulation. 7.5. Reconstructing Multilayer Genetic Networks. 7.6. Concluding Remarks. 8. A Game-Theoretic Model of Cell Crosstalk in Drug Response. 8.1. Introduction. 8.2. GameTalker: A crosstalk model of tumor-microenvironment interactions. 8.3. Modeling Personalized Cell-Cell Interaction Networks. 8.4. Reconstructing multilayer gene regulatory networks of tumor-TME interactions. 8.5. Predictive network model for cancer growth. 8.6 Concluding Remarks. 9. A Graph Model of Personalized Drug-Drug Interactions. 9.1. Introduction. 9.2. Inferring DDI networks. 9.3. Inferring dynamic DDI networks from static data. 9.4. Coalescing high-order DDIs into hypernetworks. 9.5. Learning Large-scale DDI Networks. 9.6. Concluding remarks. 10. Pharmacogenomics as a Cornerstone of Precision Medicine: Methodological Leveraging. 10.1. Introduction. 10.2. How Drug Works. 10.3. Correcting for Relatedness in Pharmacogenomics GWAS. 10.4 Family-based Designs for PGx Studies. 10.5. Intertwined Epistatic and Epistatic Networks. 10.6. Pharmacosystems Biology: from Pharmacogenomics to Pharmaco-Omics. 10.7. Concluding Remarks. |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Modern medicine is undergoing a paradigm shift from a "one-size-fits-all" strategy to a more precise patient-customized therapy and medication plan. While the success of precision medicine relies on the level of pharmacogenomic knowledge, dissecting the genetic mechanisms of drug response in a sufficient detail requires powerful computational tools. Quantitative Methods for Precision Medicine: Pharmacogenomics in Action presents the advanced statistical methods for mapping pharmacogenetic control by integrating pharmacokinetic and pharmacodynamic principles of drug-body interactions. Beyond traditional reductionist-based statistical genetic approaches, statistical formulization in this book synthesizes elements of multiple disciplines to infer, visualize, and track how pharmacogenes interact together as an intricate but well-coordinated system to mediate patient-specific drug response. Features: Functional and systems mapping models to characterize the genetic architecture of multiple medication processes Statistical methods for analyzing informative missing data in pharmacogenetic association studies Functional graph theory of inferring genetic interaction networks from association data Leveraging the concept of epistasis to capture its bidirectional, signed and weighted properties Modeling gene-induced cell-cell crosstalk and its impact on drug response A graph model of drug-drug interactions in combination therapies Critical methodological issues to improve pharmacogenomic research as the cornerstone of precision medicine This book is suitable for graduate students and researchers in the field of biology, medicine, bioinformatics and drug design and delivery interested in statistical and computational modelling of biological processes and systems. It may also serve as a major reference for applied mathematicians, computer scientists, and statisticians who attempt to develop algorithmic tools for genetic mapping, systems pharmacogenomics and systems biology. It can be used as both a textbook and research reference. It can also be used by professionals in pharmaceutical sectors who design drugs and by clinical doctors who deliver drugs"-- |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Precision medicine |
| General subdivision |
Statistical methods. |
| 9 (RLIN) |
63037 |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Precision medicine |
| General subdivision |
Mathematical models. |
| 9 (RLIN) |
63038 |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Sang, Mengmeng, |
| Relator term |
contributor. |
| 9 (RLIN) |
63039 |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Li, Feng |
| Relator term |
(Computational biologist), |
| 9 (RLIN) |
63040 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Books |