Mycobacterium ulcerans disease, also known as Buruli ulcer, is an infection caused by the Mycobacterium ulcerans bacteria. This species of bacteria is found in various aquatic environments, predominantly in areas with a humid and hot climate. It can infect humans and some other animals such as rats and cattle, causing the development of painless open wounds. Myobacterium ulcerans disease affects the skin and bones. It can lead to permanent disfiguration and long-term disability. It does not spread from one person to another. This book includes some of the vital pieces of work being conducted across the world, on the Mycobacterium ulcerans disease, and its diagnosis and treatment. The various studies that are constantly contributing towards advancement in this field are examined in detail. This book will help the readers in keeping pace with the rapid changes in this field.