Neurodegeneration is the gradual loss of neurons, and neuronal structure and function. This is the cause of neurodegenerative diseases, such as Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, etc. Research in neurodegeneration suggests that there exists several similarities between these disorders such as induced cell death and atypical protein assemblies. DNA damage accumulation has been proposed to be the causative link between neurodegeneration and aging. Several mechanisms have been implicated in the occurrence and progression of neurodegeneration, such as protein misfolding, programmed cell death, genetic mutations, various intracellular mechanisms, etc. Protein degradation is a therapeutic option for preventing the synthesis and degradation of irregular proteins that are formed in neurodegenerative disease. This book is a compilation of chapters that discuss the most vital concepts and emerging trends in neurodegeneration. Different approaches, evaluations and advanced studies have been included herein. The extensive content of this book provides with a thorough understanding of the subject.